• Home
  • Contact Us!
  • Privacy Policy

Radio Metta

  • Home
  • Business
  • Education
  • Health
  • Home Deco
  • News
  • Real Estate
  • Technology
  • Contact Us!
  • Privacy Policy
Home» Health»Discarded drug helps fight disease-causing viruses in lab

Discarded drug helps fight disease-causing viruses in lab

Saheli 29 Mar 2016 Health Comments Off on Discarded drug helps fight disease-causing viruses in lab 5 Views

STANFORD, Calif., March 28  — Researchers found a drug discarded by the company GlaxoSmithKline because of side effects during clinical trials helped human cells fight off two viruses, according to a new study.

The drug GSK983 helped cells in the lab fight off the viruses that cause dengue fever and Venezuelan equine encephalitis virus, or VEEV, suggesting it could be used to develop a broad antiviral.

While the drug helped the cells prevent infection, it also prevented them from dividing — and they died — suggesting another drug needs to be pared with GSK983 to keep cells’ ability to divide intact.

The researchers performed a genome-wide screen on the viruses, searching for methods to prevent them from infection cells. Already aware of GSK983, the researchers thought the drug could prevent the RNA-based viruses from replicating inside cells.

“The genome-wide screen carried out in the Bassik lab was really powerful, because it gave us insights into future research strategies,” Richard Deans, a researcher at Stanford University, said about the method of genomic screening developed by Dr. Michael Bassik in a press release. “I think going forward his strategy will be much more heavily used.”

For the study, published in the journal Nature Chemical Biology, researchers tested GSK983 on human cells, finding it fought off the viruses, but died days later because the drug then stopped them from dividing.

The reason for this, researchers said, is that blocking a protein key to making the building blocks of RNA prevents the viruses from copying their RNA, but cells, which also need RNA, are also prevented from creating those building blocks — which are also required to make DNA, necessary for division.

To solve this problem, the researchers introduced a slightly different building block that could only be used by the cells for DNA. The cells then fought off both viruses and continued dividing normally.

Future studies will be focused on identifying a second drug to prevent the cell death side effect, with the long-term goal of a broad-based drug to prevent infection from similar RNA-based mosquito-borne disease.

[Source:- UPI]

Discarded disease-causing Drug fight helps in lab viruses 2016-03-29
Tags Discarded disease-causing Drug fight helps in lab viruses
Facebook Twitter Stumble linkedin Pinterest More

Authors

Posted by : Saheli
Previous Article :

Russia’s Rosneft to increase 2016 investments

Next Article :

Refinery maintenance pushing gas prices high

Related Articles

Firefly Health Taps Oshi Health to Add Whole-Person Digestive Care to Its Virtual Specialty Network

Loknath Das 06 Jun 2022

This Relentless Pandemic Can Tax Your Mental Health. Here’s How to Cope

Loknath Das 11 Apr 2022

Study: Two New Early Signs of Parkinson’s Disease Identified

Loknath Das 05 Apr 2022

Latest Post

News

Your SEO Budget Is Determining Your Success

admin 03 Sep 2022
News

WAN Connection Method – Frame Relay

admin 26 Aug 2022
Education

GESS Proudly Supports and Sponsors UAE Based Team in Global STEM Challenge

Loknath Das 28 Jul 2022
Technology

The Samsung Galaxy Z Flip4 gets FCC certification

Loknath Das 22 Jul 2022
Education

USF faculty, students to present at 2022 American Educational Research Association Annual Meeting

Loknath Das 22 Jul 2022
Technology

“Critical” We Understand Digital Money’s Impact: US Policymaker

Loknath Das 07 Jun 2022
Health

Firefly Health Taps Oshi Health to Add Whole-Person Digestive Care to Its Virtual Specialty Network

Loknath Das 06 Jun 2022
May 2023
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
293031  
« Sep    
  • Home
  • Contact Us!
  • Privacy Policy
Copyright 2016, All Rights Reserved
Magazine Blog News WordPress Theme