• Home
  • Contact Us!
  • Privacy Policy

Radio Metta

  • Home
  • Business
  • Education
  • Health
  • Home Deco
  • News
  • Real Estate
  • Technology
  • Contact Us!
  • Privacy Policy
Home» Health»New subtype of prostate cancer identified by researchers

New subtype of prostate cancer identified by researchers

Loknath Das 26 Jun 2018 Health Comments Off on New subtype of prostate cancer identified by researchers 331 Views

It is imperative to get your prostate cancer screening done regularly.

Researchers have identified a new subtype of prostate cancer that occurs in about 7% of patients with advanced diseases.

The subtype is characterised by loss of the gene CDK12. It was found to be a more common in metastatic prostate cancer compared to early stage tumours that had not spread, said the study published in the journal Cell.

“Because prostate cancer is so common, 7% is a significant number,” said senior study author Arul Chinnaiyan from the University of Michigan in the US.

Tumours in which CDK12 was inactivated were responsive to immune checkpoint inhibitors, a type of immunotherapy treatment that has overall had limited success in prostate cancer, the study said.

“The fact that immune checkpoint inhibitors may be effective against this sub-type of prostate cancer makes it even more significant. This is an exciting prospect for patients who have CDK12 alterations and may benefit from immunotherapy,” Chinnaiyan added.

The researchers said they will lead a multisite clinical trial to assess checkpoint inhibitors as a treatment for metastatic prostate cancer with CDK12 loss.

In this study, the researchers looked at DNA and RNA sequencing data from 360 tumour samples from patients with metastatic castration-resistant prostate cancer.

This is an aggressive, advanced form of the disease in which the cancer has spread throughout the body and no longer responds to traditional hormone-based treatments.

The researchers found loss of CDK12 in only about 1% of early prostate cancer samples. That jumped to 7% for metastatic cancer, which indicates a more-aggressive form of the disease.

By following the mechanism of how CDK12 loss impacts the cell, the researchers found a process in which cells create neoantigens that are foreign to the immune system. This boosts immune-fighting T-cells, which may explain why these patients benefit from immune checkpoint blockade.

 

 

[“source=hindustantimes”]

by cancer identified New of prostate researchers subtype 2018-06-26
Tags by cancer identified New of prostate researchers subtype
Facebook Twitter Stumble linkedin Pinterest More

Authors

Posted by : Loknath Das
Previous Article :

When the porch decor comes out of winter storage, the magic begins

Next Article :

Online information on vaccines and autism may be unreliable

Related Articles

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members

admin 15 Sep 2025
How is PSA used to monitor prostate cancer?

How is PSA used to monitor prostate cancer?

admin 01 Sep 2025
Anatomy, Function, and Common Injuries of Hamstring Muscles

Anatomy, Function, and Common Injuries of Hamstring Muscles

admin 12 Aug 2025

Latest Post

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members
Health

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members

admin 15 Sep 2025
Small, Rural Central California High School Continues To Defy Standardized Education
Education

Small, Rural Central California High School Continues To Defy Standardized Education

admin 12 Sep 2025
Speeches delivered by CEO Sundar Pichai at the White House AI Education Taskforce
Education

Speeches delivered by CEO Sundar Pichai at the White House AI Education Taskforce

admin 08 Sep 2025
How is PSA used to monitor prostate cancer?
Health

How is PSA used to monitor prostate cancer?

admin 01 Sep 2025
The Future of High Performance Networking: Ultra Ethernet Explained
Technology

The Future of High Performance Networking: Ultra Ethernet Explained

admin 28 Aug 2025
Why a focus on foundational education must be at the heart of the response: Out of school but not out of reach
Education

Why a focus on foundational education must be at the heart of the response: Out of school but not out of reach

admin 23 Aug 2025
October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
  • Home
  • Contact Us!
  • Privacy Policy
Copyright 2016, All Rights Reserved
Magazine Blog News WordPress Theme