• Home
  • Contact Us!
  • Privacy Policy

Radio Metta

  • Home
  • Business
  • Education
  • Health
  • Home Deco
  • News
  • Real Estate
  • Technology
  • Contact Us!
  • Privacy Policy
Home» Health»Two fisted, antibody approach could effectively kill ovarian cancer

Two fisted, antibody approach could effectively kill ovarian cancer

Loknath Das 05 Sep 2018 Health Comments Off on Two fisted, antibody approach could effectively kill ovarian cancer 751 Views

Ovarian cancer,Cancer,Ovarian cancer cure

Researchers have developed a two fisted, antibody approach that can effectively destroy ovarian cancer – the deadliest gynecological disease – and could also be utilised to kill breast, prostate and other solid tumours.

According to Jogender Tushir-Singh from the University of Virginia’s (UVA), a major problem with immune therapies for ovarian cancer is that the immune cells intended to kill the cancer cells could not infiltrate the solid tumour bed effectively. So he engineered an antibody that he likens to a “two-headed arrow”.

One head of this dual pronged ‘arrow’ strikes what is known as the death receptor on the cancer cells, forcing them to die, while the other head strikes a receptor known as FOLR1, a well established marker that suggests a poor prognosis.

“There are a lot of efforts in terms of cancer immune therapy, but the success of these are really limited in solid tumours,” Tushir-Singh said.

“I found that one of the problems is with the solid tumour microenvironment.

“The microenvironment is highly hypoxic, anergic and, particularly in the case of ovarian cancer, some unusually large receptors form a protective fence around tumour cells, so even if the immune cells reach there, there are many obstacles,” he explained.

The newly engineered antibodies are over 100 times more effective at killing cancer cells than the antibodies that have made it to clinical trials. Further, the approach also avoids toxicity issues that have plagued previous antibody therapies.

“Liver toxicity has been the biggest problem for a lot of antibodies – they are taken out of the blood too fast and accumulate where not needed,” Tushir-Singh said.

“But by providing a good home for the antibodies in the tumour, we are keeping these antibodies away from the liver,” he noted.

[“source=hindustantimes”]

antibody Approach cancer could effectively fisted kill ovarian two 2018-09-05
Tags antibody Approach cancer could effectively fisted kill ovarian two
Facebook Twitter Stumble linkedin Pinterest More

Authors

Posted by : Loknath Das
Previous Article :

Kyle Richards Decorates Daughter Sophia’s ‘Retro Glam’ Dorm Room: ‘Now it Feels Like Home’

Next Article :

Genetic mutations could be responsible for driving tumour formation

Related Articles

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members

admin 15 Sep 2025
How is PSA used to monitor prostate cancer?

How is PSA used to monitor prostate cancer?

admin 01 Sep 2025
Anatomy, Function, and Common Injuries of Hamstring Muscles

Anatomy, Function, and Common Injuries of Hamstring Muscles

admin 12 Aug 2025

Latest Post

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members
Health

Digital Dermatology with Freedom 360: Skin Cancer Checks and Expert Care for Members

admin 15 Sep 2025
Small, Rural Central California High School Continues To Defy Standardized Education
Education

Small, Rural Central California High School Continues To Defy Standardized Education

admin 12 Sep 2025
Speeches delivered by CEO Sundar Pichai at the White House AI Education Taskforce
Education

Speeches delivered by CEO Sundar Pichai at the White House AI Education Taskforce

admin 08 Sep 2025
How is PSA used to monitor prostate cancer?
Health

How is PSA used to monitor prostate cancer?

admin 01 Sep 2025
The Future of High Performance Networking: Ultra Ethernet Explained
Technology

The Future of High Performance Networking: Ultra Ethernet Explained

admin 28 Aug 2025
Why a focus on foundational education must be at the heart of the response: Out of school but not out of reach
Education

Why a focus on foundational education must be at the heart of the response: Out of school but not out of reach

admin 23 Aug 2025
October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
  • Home
  • Contact Us!
  • Privacy Policy
Copyright 2016, All Rights Reserved
Magazine Blog News WordPress Theme